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Human tendon-on-a-chip for modeling the myofibroblast microenvironment in peritendinous fibrosis

poster
posted on 2025-02-25, 18:41 authored by Isabelle LinaresIsabelle Linares, Raquel Ajalik, Rahul Alencherry, Victor Zhang, James McGrathJames McGrath, Hani Awad

Poster presented at the Orthopaedic Research Society Meeting in Phoenix, Arizona in February 2025. The contents include figures published in the Advanced Healthcare Materials paper linked below. We demonstrate the development of a tissue chip platform designed to study tendon inflammation and fibrosis. The poster figures detail the phenotype validation of the tendon-on-a-chip model and a proof-of-concept study to screen a potential therapeutic.

Funding

A microphysiological system of tendon inflammation and fibrosis for drug screening and efficacy testing

National Center for Advancing Translational Sciences

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