A fluid dynamics simulation was performed in COMSOL Multiphysics to model the fluid profile in the flow insert channel of a microfluidic device. Laminar flow physics was applied to the channel geometry, and a no-slip boundary condition was selected at the walls. The inlet flow rate was set to a constant value and was simulated across a range from 10 to 1000 µl/min. A pressure P = 0 was applied to the outlet. A physics-controlled mesh was generated and a stationary parametric sweep study was executed to generate shear stress and velocity profiles.
Funding
A microphysiological system of tendon inflammation and fibrosis for drug screening and efficacy testing
National Center for Advancing Translational Sciences